| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Salacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profile
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| Autores: |
Vellosa,José Carlos Rebuglio
Khalil,Najeh Maissar
Gutierres,Vânia Ortega
Santos,Vânia Aparecida de Freitas Formenton Macedo dos
Furlan,Maysa
Brunetti,Iguatemy Lourenço
Oliveira,Olga Maria Mascarenhas de Faria
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| Data: |
2009-03-01
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| Ano: |
2009
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| Palavras-chave: |
Salacia campestris Walp/antioxidant properties
Hippocrateaceae
Myeloperoxidase
Reactive oxygen species
Antioxidants
Free radicals
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| Resumo: |
Reactive oxygen species (ROS) and free radical species have been implicated in initiating or accompanying many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Salacia species have long been used, in several countries, as traditional medicines against certain diseases and for their anti-inflammatory properties. In this study, Salacia campestris Walp (Hippocrateaceae) root bark ethanol extract (ScEtOH) was assessed for its ability to scavenge free radicals and reactive oxygen species; the results were expressed as percentage inhibition of the active species. ScEtOH was efficient against studied species: DPPH radical (obtained inhibition = 30%), ABTS+ (IC50 = 1.8±0.8 μg/mL), HOCl (IC50 = 1.7 ± 0.1 μg/mL), O2- (obtained inhibition = 32%), and NO (obtained inhibition = 18 %). Peroxidase activity inhibition was evaluated through the guaiacol oxidation reaction catalyzed by hemin, HRP and myeloperoxidase (MPO); data showed that ScEtOH at 10 μg/mL led to 54 and 51% of inhibition, respectively, for the hemin and HRP systems. In the MPO system, ScEtOH promoted a 50% inhibition at 8.9 μg/mL, whereas quercetin, a powerful MPO inhibitor, inhibited this system at 1.35 μg/mL.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100012
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502009000100012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.45 n.1 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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